Emotional disturbances such as anxiety, fear, depression and aggression are\noften experienced by patients with temporal lobe epilepsy. These psychiatric\nsymptoms may occur during or just after (postictal) a seizure; however, in\nsome patients, they occur interictally (i.e. between seizures) and may profoundly\nchange the individualâ??s personality. Aside from confirming that a significant\nproportion of temporal lobe epileptics do suffer from interictal abnormal\nemotionality, there has been little progress to date in identifying the\nfundamental nature of these disturbances. There is a lack of evidences regarding\nthe influence of activation of emotiogenic structures and emotional behavior\non development of seizures. Kindling is a commonly used animal model\nfor study of interictal emotionality and the effects of kindling and human epilepsy\non emotional behavior are the primary focus of investigators and not\nvice versa. Respectively, the interrelation between emotional and seizure reactions\nwas studied in Wistar albino rats. In our study we tried to elucidate: can\nemotional behavior evoked by stimulation of the emotiogenic zones of the\nhypothalamus or of induction of acute pain stress modify manifestations of\ngeneralized seizures within the period where a â??fullâ? epileptic syndrom has\nbeen stable formed earlier? Our leading hypothesis is as follow: the emotional\ndisturbances can be considered as the emergence of instinctive behavior with\nan adaptive significance of defense and as a by-product of the inhibitory\nprocesses that build up to protect against the future occurrence of seizures.
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